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If you have been on your GLP-1 medication for an adequate trial period (typically 12 to 16 weeks at the maintenance dose) and aren't seeing the expected results, your provider has several options

Liver Fat (MASLD) A Phase 2 trial showed retatrutide reduced liver fat by 82%

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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Muller TD, Finan B, Bloom SR

Most people report skin improvement around the 8- to 12-week mark, which tracks with the timeline we expect for systemic inflammation to start meaningfully decreasing. I think the better way to look at it is about reaching a goal of improved metabolic health, says Dr