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TFCE corrected) which estimated the group mean spatial distribution of [11C]Raclopride displacement using a one-tailed one-sample t -test

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3 Results 3.1 Development and verification of PBPK model in adults Observed plasma drug concentration data of adults receiving 5 mg single dose of tirzepatide in a clinical trial (Figure 2A), data from 5 clinical studies covering a broad range of 0.2515 mg in single (Figures 2BH) and multiple (Figures 3AE) dosing regimens were used as testing dataset for model external verification

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Clinical studies demonstrate that GLP-1 receptor activation reduces ghrelin levels by up to 20-30% in some patients, while simultaneously enhancing peptide YY (PYY) and cholecystokinin (CCK), both powerful satiety messengers