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While semaglutide was associated with a significantly reduced risk of ADRD incidence in both patient groups, the association was stronger in younger adults than in older adults with largely non-overlapping confidence intervals (Supplemental Figures 13 and 14)

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While DPP-4 is expressed in mouse and pig pancreatic endocrine cells [26, 27] within the pancreatic duct, and in pancreatic alpha cells in humans [28, 29], glucagon is not one of its major substrates

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Post-marketing surveillance, case reports, and patient community posts do include dry mouth among reported complaints