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(2) Clinical design deficiencies: most human trials utilize berberine chloride formulations not optimized for obesity-specific indications, coupled with inadequate endpoint selection targeting adiposity pathophysiology

Yet many patients are prescribed them with little discussion beyond body weight, nausea, constipation, and refill timing

doi: 10.1002/art.23807

This typically includes regular assessment of vital signs (heart rate, blood pressure), weight and body composition, laboratory parameters (electrolytes, kidney function, lipid panel, hemoglobin A1c if diabetic), mental health status, and gastrointestinal symptoms

But are they suitable for other people

doi: 10.1016/j.cmet.2018.03.001 [DOI] [PubMed] [Google Scholar] 97
