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RCT SCALE Study - Liraglutide vs Placebo for Weight Loss in Overweight Nondiabetic Adults, NEJM (2015) [PubMed abstract] The SCALE study enrolled 3731 overweight adults who did not have diabetes Main inclusion criteria BMI 30
These two peptides (GLP-1 and GIP) potentiate glucose-stimulated insulin secretion in an additive manner, likely contribute equally to the incretin effect and together can fully account for the majority of the incretin effect in humans
10.1111/j.1365-2826.2012.02381.x 64 ZhaoP.LiangY
Nevertheless, tirzepatide use seemed to be associated with a higher risk (RR 1.97, 95% CI 1.143.42, p = 0.558) [129]
GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study
