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doi: 10.1016/j.ebiom.2021.103242 11 CaoCYangSZhouZ

This view is congruent with our exploratory analyses finding no evidence for DA release of a similar magnitude and reliability during the volatile period (Supplementary Fig

Diabetes 2026, 75 DOI: 10.2337/db26-2813-lb.Peer-Reviewed Original ResearchConceptsRate of treatment discontinuationClinically meaningful weight lossVolume-matched placeboGLP-1/GIP receptor agonistsObesity-related conditionsIncretin classSafety/tolerability profileTreatment discontinuationDouble-blindPlacebo-ControlledPrimary endpointReceptor agonistsMulticenter trialGI eventsAdverse eventsEfficacy estimandPfizer Inc.Dose responseRoche PharmaceuticalsBMIWeight lossOverweight/obesityPrediabetesAmgen Inc.Baseline 205

J., Gallwitz, B., Schmidt, W

Using expired or improperly stored semaglutide may reduce its effectiveness