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Weight Loss and Caffeine Tolerance As body weight decreases, caffeine distributes differently in the body

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The chronic activation of microglia can convert astrocytes into a neurotoxic A1 phenotype (Yun et al., 2018) by secreting different molecules such as TNF-, IL-1, nitric oxide, vascular endothelial growth factor-B, or complement factor Cq1 (Haidet-Phillips et al., 2011