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You need to do whats called a randomized trial, where you give half of people a drug like semaglutide and half of the people not, then you follow them to see if there are lower rates of depression

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The PlexusDx Precision Peptide Genetic Test analyzes 14 pathways and 49 peptidesincluding GLP1R and GIPR variantsto predict treatment efficacy and tolerance profiles

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In severe forms, it can affect your ability to walk or stand