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We defined somatic comorbidity as having type 1 and 2 diabetes (ICD-10: E10, E11, E14), obesity (ICD-10: E66), heart disease (ICD-10: I20-I25), stroke (ICD-10: I61, I63, I64, G45) within 10 years prior to index date

For most adults with newly diagnosed type 2 diabetes without cardiorenal disease, metformin plus lifestyle modification remains initial therapy, with GLP-1 agonists as preferred second-line agents

Supporting insulin release: GLP-1 enhances insulin secretion in response to food, especially when blood sugar levels rise

Some things scientists did back in the day seem primitive or ignorant now

That growth is driven almost entirely by the success of prescription GLP-1 drugs and the desire of consumers to access similar benefits without injections, prescriptions, or high costs

Zepbounds effects also showed up in surprising ways
