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Description
In contrast, DPP-4 expressed within murine hepatocytes, adipocytes, or gut enterocytes is not required for physiological regulation of glucose tolerance and is dispensable for the glucoregulatory actions of DPP4i (20, 2325)

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The potential role in stroke management, prevention of obesity-induced cognitive impairment, and protection against sepsis-induced brain dysfunction add layers to its therapeutic potential

Indications and Usage Ozempic (semaglutide) injection 0.5 mg, 1 mg, or 2 mg is indicated: as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes and established CV disease to reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease Important Safety Information for RYBELSUS WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

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