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In addition to needing long-term data in primary CV prevention populations, further research evaluating the CV effects of other GLP-1RA and SGLT2-I is required to understand whether such findings are agent or dose dependent

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Further microscopy experiments performed to visualise GLP-1R engagement with EGFP-VAPB in response to exendin-4 stimulation include confocal imaging of serial optical sections covering the entire cell thickness after SNAP/FLAG-hGLP-1R surface labelling with a membrane impermeable SNAP-tag probe followed by exendin-4 stimulation, represented as a maximum intensity projection (MIP) in Fig

Emerging data also point to a broader neuropsychiatric profile of GLP-1 RAs, with preliminary evidence suggesting benefits across multiple domains, including cognitive function, suicidality, anxiety, substance use, and binge-related eating behaviors

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Similarly, researchers have proposed that the primary products of alpha-cell proglucagon processing are reflective of alpha-cell maturity state ( Figure 3 )