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Fear of long-term effects: Given the ongoing discussions about risks in the medical community, some patients may have concerns about the long-term impact of GLP-1 medications, including dangerous adverse reactions as described on the FDA warning label, like acute kidney injury and hypoglycemia

The global GLP-1 market exceeded $70 billion in 2025 and is projected to reach over $200 billion by 2033 ( [17] )

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Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg and gradually titrated upward (5 mg, 7.5 mg, 10 mg, 12.5 mg, to a maximum of 15 mg) based on therapeutic response and tolerability

Alcohol tolerance typically decreases on GLP-1 therapy

Osteoporos Int 36 , 21152126 (2025)