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Despite lacking the exendin 2029 sequence RLFIEWLKNG, GLP-1 and liraglutide exhibit analgesic effects, potentially through direct interactions with the TRPV1 receptor

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The semaglutide group achieved a weight loss of 10.5% at 72 weeks compared with 2% for adults receiving placebo (estimated difference, 8.5 percentage points

doi: 10.1152/ajpendo.1999.277.5.E937

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Among these, five (55.5%) demonstrated reductions in total daily insulin requirements