are there natural glp-1 agonists Current Insights, Advantages and Challenges of Small Molecule Glucagon-like Peptide 1 Receptor Agonists: A Scoping Review Natural GLP-1 Discovery Hidden in

14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below

GLP-1 Medications Currently Available in Canada Semaglutide (Ozempic for diabetes, Wegovy for weight management) and tirzepatide (Mounjaro for diabetes) are Health Canada-approved and available via prescription

The CV benefits extend to the promising effects in improving HF outcomes

NakanishiRTanakaMNisaBUShimizuSHirabayashiTTanakaMet al

FDA cleared its Phase 1 Investigational New Drug application on June 23, 2026

Consequently, PYY and GLP-1 thus make us feel full