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Given the frequent co-existence of NASH and T2DM, combination nanotherapies co-delivering GLP-1RAs with agents such as farnesoid X receptor (FXR) agonists or GS-834,356 offer a multi-pronged strategy targeting both metabolic and fibrotic pathways [243, 257, 258]

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52 As previously reported, GLP-1RAs promote antihypertensive effects by enhancing vasodilation through nitric oxide production and modulating the RAAS, reducing plasma angiotensin II levels

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