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Discussion The emerging evidence on GLP-1RAs presents a promising and mechanistically distinct approach to treating SUDs

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Tirzepatide received approval from the U.S

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The reports have been submitted through the agencys publicly accessible adverse events tracking system, and the agency said theres not always enough information in those reports to properly evaluate them

however, gastrointestinal adverse effects such as nausea, vomiting, and diarrhea are the most frequently reported, particularly during the initial treatment phase ( Additionally, weight loss with GLP-1 RAs is accompanied by reductions in lean mass, with skeletal muscle accounting for approximately 15%40% of total weight loss ( 6 Conclusion and future directions The data strongly supports that SLD, is fueled by common pathways of altered metabolism and chronic inflammation, which are the central precipitating factors for HCC development across MASLD, ALD, and to some extent, chronic viral etiologies