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The medication makes the process more achievable, but the strategy makes it successful

Whilst not primarily a weight-loss medication, metformin often leads to modest weight reduction or weight stabilisation, making it particularly suitable for patients with both diabetes and obesity

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Unlike tirzepatide (Mounjaro, Zepbound) it is a dual GIP/GLP-1 agonist that is FDA approved

Orlistat In a 24-week clinical study, orlistat reduced body weight by 4.65 kg

If you stop tirzepatide and wait two weeks (roughly four half-lives) before starting retatrutide, the previous medication will have largely cleared, and you are starting closer to baseline
