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Common reasons include side effects (particularly nausea and vomiting), cost of ongoing private prescription, insufficient weight loss at tolerated doses, or switching to Mounjaro after learning about the SURMOUNT-5 trial results showing tirzepatides greater average efficacy
doi: 10.1016/S0140-6736(17)32400-5

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MRI-based studies from the SURPASS-3 program and related tirzepatide trials show that tirzepatide produces large reductions in visceral and liver fat while preserving a higher percentage of lean muscle

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