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Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet

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The spacer between the stearic di-acid chain and peptide backbone has been optimized [62], and the spacers composed of Glu or 8-amino-3,6-dioxaoctanoic acid (ADO) were found to be optimal for the potency of GLP-1 RAs, though mechanisms are not clear