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The survival benefit was more pronounced in younger people and those with cardiometabolic comorbidities, highlighting the need for a careful riskbenefit evaluation when prescribing GLP-1 RAs in high-risk individuals.

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Participants received diet (500kcaldeficit per day) and exercise counseling during 2-week run-in, before being randomly assigned (with a telephone or web-based system) to once-daily subcutaneous liraglutide (1.2, 1.8, 2.4 or 3.0mg, n=9095), placebo (n=98) or open-label orlistat (120mg 3, n=95)