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Chemical modifications, such as amino acid mutations, addition of fatty acid chains, or design of synthetic analogs, can enhance their resistance to enzymatic degradation and significantly improve metabolic stability and half-life (Yu et al., 2018

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[DOI] [PubMed] [Google Scholar] 55.Tuttle K.R., Rayner B., Lakshmanan M.C., et al

Both compounds require gradual dose escalation

They also suppress glucagon secretion that elevates blood sugar, thus tightly controlling glucose levels without causing hypoglycemia

A Review on Semaglutide: An Oral Glucagon-Like Peptide 1 Receptor Agonist in Management of Type 2 Diabetes Mellitus