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The safety profile in participants with HF at baseline indicates that serious adverse events were reported in 53.8% of the oral semaglutide group and 57.1% of the placebo group

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Acknowledgements We thank Beat Lutz for the GAD65 cDNA, Margaret Morris for critically reading the manuscript, and Claudia Klugmann for technical assistance
AICAR is a known activator of AMPK

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