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The majority of thyroid adenoma functions normally, producing a normal level of thyroid hormone (euthyroid) 13

Conversely, smoking may decrease the efficacy of pentoxifylline due to induction of hepatic enzyme activity and should be avoided or minimized during treatment

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SGLT2i are a class of drugs that we hypothesize may have a beneficial effect on these pathways 4 that are not well targeted by current treatment paradigms

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Patients not on antihyperglycemic agents at study entry (N=550) with inadequate glycemic control (A1C 7.5% to 11%) immediately entered the 2-week single-blind placebo run-in period and then were randomized