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What comprehensive treatment actually looks like: My typical approach with a patient who might benefit from a GLP-1 looks something like this: We start with thorough assessment

Even if GLP-1 and GIP secretion are present in these scenarios, both hormones usually have decreased effectiveness

GLP-1 RAs can also cause bloating and burping, partly from delayed stomach emptying (food sits and ferments longer in the gut) and perhaps changes in gut bacteria

However, when semaglutide was studied at higher doses for obesity under the Wegovy brand, a different picture emerged

GLP-1 treatments start at $179, while GLP-1 + GIP programs begin at $259

It is unclear why directionality would vary between studies, although we note these studies were performed in specific disease contexts, and are in substantially smaller samples