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The American Heart Association has explicitly supported these medications for mitigating outcomes associated with atherosclerotic cardiovascular disease, including myocardial infarction, stroke, and cardiovascular death (Marx et al

24 but it contradicts the model constructed by Zhang et al that Lys 197 of GLP-1R is highly conserved and is hydrogen bonded to Thr 13 of GLP-1

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Mouhammad ZA, Rombaut A, Bermdez MYG, Vohra R, Tribble JR, Williams PA, Kolko M (2025) Systemic semaglutide provides a mild vasoprotective and antineuroinflammatory effect in a rat model of ocular hypertensive glaucoma