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This matters later in two places

Diamant M, Van Gaal L, Stranks S, Northrup J, Cao D, Taylor K, et al

Adding resistance training or changing cardio modalities can overcome plateaus by preventing metabolic efficiency that limits fat loss

Patients should be monitored so that they lose weight at a healthy rate

Once opened, the medication can be stored at room temperature (up to 30C) for a maximum of 28 days

Long-term success tends to correlate with adherence to dosing instructions, tolerance of dose escalation, and sustained lifestyle adjustments rather than willpower alone