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While the absolute risk is still relatively low, the relative increase is significant , especially considering the sheer number of people using these drugs today

Benton, M

Evers, R

Adding the genetic test after your first month of therapy helps confirm you're on the right medication and dosing path for your unique biology

Clinical trials have demonstrated impressive results, with many participants experiencing significant reductions in body weight

However, oral weight-loss medications do exist: oral Wegovy (semaglutide) was approved in late 2025, and Foundayo (orforglipron), an oral GLP-1 pill from Eli Lilly, was FDA-approved in April 2026