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Description
Short-acting GLP-1RA (e.g., exenatide, lixisenatide) more prominently delays gastric emptying [70] but generally produces more modest and earlier-plateauing weight loss [71]
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They work by: Reducing amyloid-beta plaque accumulation Decreasing neuroinflammation (IL-1, TNF-) Improving synaptic plasticity and memory Clinical studies like the EVOKE and EVOKE+ trials are now investigating Semaglutide for its potential to slow Alzheimers progression

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Chen C, Zhou R, Fu F, Xiao J (2023) Postmarket safety profile of suicide/self-injury for GLP-1 receptor agonist: a real-world pharmacovigilance analysis
