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GLP-1 can result in considerable weight reduction, with individuals experiencing an average loss of 10-20% of their total body weight

This analysis of survey data finds that over 40% of adults under 65 with private insurance could be indicated for a GLP-1 drug though relatively few have a claim, suggesting that a much smaller share seeks treatment through healthcare providers.

Background Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) reduce the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM)

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The mechanisms underlying these effects involve the modulation of signaling pathways associated with cell growth, survival, and metabolism

The gut microbiome influences many aspects of metabolic health including digestive signaling, short-chain fatty acid production, immune communication, and gut barrier integrity