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When their respective postprandial concentrations were increased through exogenous infusion, GLP-1 elicited a more robust insulin response, suggesting its superior potency compared to GIP as an incretin (55)

Who gets it: Your doctor may prescribe Qsymia if your BMI is 30 or higher, or 27 with conditions like high blood pressure or diabetes

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As a neuromodulator, it is capable of modulating both pre- and postsynaptic pathways, affecting glutamatergic and GABAergic neurotransmission [17]

81 When adjuvant medicines such as metformin are initiated to improve weight outcomes in people with SMI, they have also been found to improve antipsychotic adherence

GLP-1 receptor agonists are typically recommended after trying metformin and other treatments, usually as a third-line option or in specific circumstances such as when weight loss would benefit other obesity-related comorbidities