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This compound also demonstrates anti-inflammatory effects on vascular endothelium and has shown cardioprotective signals in large-scale clinical research

A recent multi-society joint guidance statement advocated for an individualized approach based upon each patients unique factors rather than a one-size approach of holding this medication for all patients undergoing procedures [215]
[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Cappellani F, Regillo CD, Haller JA, Gagliano C, Pulido JS

[15] In August 2024, the SURMOUNT-1 three-year study (176-week treatment period) found that tirzepatide reduced the risk of developing type 2 diabetes by 94% in adults with pre-diabetes and obesity or overweight

While in SUSTAIN-6, a sharper decline (46%) in macroalbuminuria seems to be entirely due to the semaglutide treatment than a 26% fall in macroalbuminuria by liraglutide [22]
