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(2017) Nature 546 : 312-315 PubMed: 28514449 Search on PubMed DOI: Primary Citation Related Structures: 5VEW, 5VEX PubMed Abstract: The glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have opposing physiological roles in insulin release and glucose homeostasis

There are two main trials (FIGHT and LIVE trials) demonstrating that treatment with liraglutide increased the risk of adverse heart failure-associated outcomes in patients with heart failure and reduced LVEF [43-45]

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Estimates of Diabetes and Its Burden in the United States

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