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According to a case report published in the Journal of Investigative Medicine in October 2021, a 52-year-old female taking semaglutide reported experiencing severe gastric pain, accompanied by fullness, bloating, and vomiting within one month of starting weekly injections

If GLP1 receptor agonists do not cross the BBB, neuroprotective effects would have to be achieved primarily by these drugs acting on GLP1 receptors outside the BBB

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Nausea is the most frequently reported symptom during this window, often described as mild queasiness rather than severe vomiting

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