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One of the first reasons why polymers dominate is their good level of safety

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Even if significant dose volume adjustments are necessary to effectively treat the new condition with a different route of administration and/or dosing, the imputed price (at parity price/unit with the first indication) may not be sufficient to realize the difference in value in the new indication due to higher disease burden, unmet need, or efficacy

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Generic metformin, also used to treat diabetes, is associated with utilization management tools in only 30% of ACA Marketplace plans, almost exclusively in the form of quantity limits

Fundoscopic examination revealed pronounced optic disc edema in OS, with OCT showing intra- and subretinal fluid extending into the nasal macula reaching fovea centralis