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The answer might depend on the individual, their age or health status, or what they are using the drug for

Further, active forms of GLP-1, as well as inactive metabolites, are rapidly eliminated by the kidneys (11, 13)

Weve seen external swelling, internal fluid shifts, headaches, stiffness, and, in rare cases, isolation of pro-growth signaling that could theoretically interact with cancer biology

Here is the practical framework for thinking through it

It is especially recommended for those who are overweight or obese and not at glycemic goals despite aggressive insulin therapy