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Description
The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary

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Patients with IBS-D (diarrhea-dominant) sometimes experience reduced urgency and improved stool consistency, while those with IBS-C (constipation-dominant) often report worsening constipation and bloating

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[DOI] [PubMed] [Google Scholar] 197.Giuse NB, Koonce TY, Kusnoor SV, et al

Oncogene 13 , 625632 (1996)
