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Description
Exceedingly short half-life (12 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question

All ductal pancreatic carcinomas are GLP1R negative, whereas 6/20 PanIN 1/2 and 0/12 PanIN 3 express GLP1R

The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects
GLP-1 treatment for PCOS including semaglutide, oral options, and individualized dosing from PCOS specialists

And I have plenty of thoughts on the matter.

GLP-1 therapies, such as Zepbound (tirzepatide), address obstructive sleep apnea by aiding weight management, thereby reducing airway pressure and improving respiratory health
