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This paragraph has been medically reviewed by our Medical Director, Dr

In the 72-week SURMOUNT-1 trial, tirzepatide was tested for weight loss in people with obesity, with the following results

But these health issues may raise your risk: Diabetes High blood pressure High cholesterol Obstructive sleep apnea Taking certain medications (PDE4 inhibitors) Smoking Eye problems that can increase your risk include: Previous NAION in one eye A naturally crowded optic nerve (called disk at risk) Having prior eye surgery You can still take semaglutide or other GLP-1 drugs if you have these conditions

Some of the common side effects associated with these medications include: feeling sick (nausea) being sick (vomiting) constipation stomach pain weakness or tiredness headache dizziness gas bloating mood changes heartburn or indigestion injection site reactions Some of the less common but severe side effects include: allergic reactions (difficulty breathing and swallowing, wheezing, face or lip swelling, dizziness, and body rash) hip fractures inflamed pancreas (pancreatitis, which may cause severe and persistent stomach pain or vomiting) kidney or bladder stones Most mild side effects will clear up on their own within a few months, once your body has got used to the new medication

Combining both can improve contour

Patients with a naturally smaller optic disc (where the nerve connects to the eye) are already at higher risk for NAION, according to the American Optometric Association