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GMP refers to the Good Manufacturing Practice Regulations promulgated by the US Food and Drug Administrations under the authority of the Federal Food, Drug, and Cosmetic Act

Patients with severe renal or hepatic disease, active pancreatitis, or diabetic retinopathy requiring urgent intervention need careful evaluation before starting or modifying any GLP-1 dosing regimen

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Figure 1 Discussion In the presented case of a newly diagnosed patient with type 2 diabetes, euDKA occurred at the very early onset after initiation of combined therapy with GLP-1RA and SGLT2i, in the absence of infection or other precipitating factors (such as alcohol overdose, pancreatitis, pregnancy), and proved refractory to standard therapy with insulin, glucose, and fluid resuscitation