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Still other factors might also play a role

The NEJM trial, the PMC review by Katsi et al

Didnt have severe insulin resistance, metabolic syndrome, or diabetes before starting Realistic expectations

[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD

Treatment typically begins at a lower starting dose, which is gradually adjusted under medical supervision to reduce side effects and support safe progress
