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Away from the ventricular edge, in the area of moderate reactive glial changes within the ventromedial hypothalamic nucleus, a significant reduction in AQP4 and Cx43 immunostaining was observed (Figs 2, 3)
Semaglutide GLP-1 affects the area of the brain responsible for curbing hunger and prolonging feelings of satiation after eating

doi: 10.1001/archinte.166.22.2502 [DOI] [PubMed] [Google Scholar] 106

Because hunger is genuinely suppressed, sticking to a 500750 calorie daily deficit feels manageable rather than willpower-dependent

Although insulins vasoactive effects appear to be altered in skeletal muscle, this finding may also reflect changes in whole-body perfusion, underscoring the importance of assessing systemic blood flow when investigating tissue-specific vascular responses
