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Moving from Zepbound to Retatrutide, or vice versa, sometimes produces additional weight loss, likely reflecting differences in individual receptor sensitivity

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Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation

The answer to how GLP-1 agonists affect the brain could, of course, be all of the above

Additionally, immunofluorescence staining for GLP-1R, along with markers for glutamatergic and GABAergic neurons, revealed that GLP-1R is predominantly expressed in glutamatergic neurons within the BLA