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Simultaneously, sympathetic nervous system activity measured by HR variability and the rate-pressure-product were also elevated, and increases in HR, systolic BP and sympathetic nervous system activity were still observed even with a concomitant L-NMMA-infusion [38]

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EClinicalMedicine 57 , 101865 (2023)

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In fact, albiglutide and dulaglutide had the fastest brain uptake, followed by DA5-CH, whereas tirzepatide had a slow brain uptake [35]