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That means: Your body also develops a tolerance to the GI side effects over time, which is why patients who start carefully can tolerate higher doses later in treatment that would have been overwhelming at week one

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But digestive side effects like diarrhea and vomiting can cause additional losses through the GI tract

When you eat, GLP-1 helps your pancreas release insulin to lower blood sugar, and it also slows down how quickly food leaves your stomach, making you feel fuller for longer

Small observational studies and posthoc analyses of trials primarily designed for metabolic endpoints have hinted at mood improvements

Additionally, it occupies GIP receptors and mimics the action of the GIP hormone to enhance insulin release and promote fat breakdown