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Network meta-analysis of treatments for type 2 diabetes mellitus following failure with metformin plus sulfonylurea

For example, in a study on 36 DM patients treated with BBR (500 mg three times daily) for 13 weeks, 34.5 % experienced flatulence, diarrhea, abdominal pain, or constipation [7]

At 48 weeks, relative liver fat reductions reached -81.7% and -86.0% with 8mg and 12mg doses respectively

The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)

The reduction of cardiovascular events is not only related to anti-diabetic properties, but also to pleotropic effects leading to the reduction of the residual cardiovascular risk, that has been defined as the risk of progression of CV events (MACE or HF) that remains after the optimal glycaemic control in T2DM patients, and it seems to be related to meta-inflammation, defined as a low-grade chronic and sterile inflammatory status

Its dosing regimen starts gradually, increasing over time to the full 2.4 mg maintenance dose