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Description
The dual agonism of GLP-1 and GIP receptor was achieved by replacing the tryptophan cage of exendin-4 with the C-terminal undecapeptide sequence of oxyntomodulin along with a single amino acid substitution from histidine to tyrosine at the amino terminus of the peptide

In addition, in a pre-print publication this year, researchers analyzed real-world effectiveness of GLP-1 usage compared to regular care management in a control group

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7 This preclinical work has now been translated to a population of patients with raised ICP due to IIH

Data from only three groups (vehicle, AMG 133 0.25 mg kg 1 and AMG 133 0.75 mg kg 1 ) are reported and discussed in this publication

doi: 10.1111/obr.12815
