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Quick Answer: Semaglutide does not directly cause urine odor changes, but the metabolic effects of weight loss, ketosis, dehydration, and dietary modifications during treatment can indirectly alter urine smell

[Google Scholar] 6.GBD 2021 Demographics Collaborators, Schumacher AE, Kyu HH, Aali A, Abbafati C, Abbas J, et al

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A composite outcome of (1) an HbA1c 6.5% together with (2) 10% WL and (3) without episodes of severe or clinically significant hypoglycemia was achieved by 22% of participants at the semaglutide 1 mg group, compared to 32% to 60% at the tirzepatide 5 to 15 mg groups after 40 weeks of treatment, demonstrating the potential of tirzepatide to improve further the current management of people with T2DM and obesity compared to the currently used GLP-1 RAs

Guardado-Mendoza R, Prioletta A, Jimenez-Ceja LM, Sosale A, Folli F

Some ulcerated lesion may improve with split-skin grafting