glp 1 cause hypoglycemia glp-1_analogs [TUSOM Frontiers | Glucagon in metabolic

This was the basis for the FDA's August 2025 approval

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Bioorganic & Medicinal Chemistry 17, 1783-1802

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Our findings reveal that tirzepatide attenuates alcohol-induced dopamine signalling, reduces alcohol consumption, and suppresses relapse-like behaviours. Because alcohol, nicotine, and many drugs of abuse hijack the brains reward circuitry, dampening dopamine spikes could help explain why alcohol seemed less compelling to the animals