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Description

American Journal of Physiology Endocrinology and Metabolism

Clinical evidence shows that most people regain significant weight within months of stopping these drugsresearch suggests 50% of lost weight returns within one yearmaking a structured approach to tapering essential rather than abrupt cessation

Chronic hyperglycemia in diabetes downregulates GIP receptor (GIPR) expression and impairs GIP-mediated insulin secretion [21], rendering high-doses of GIP infusions ineffective [22]

Possible complications Complications that require urgent surgery are rare (about 1 in 1,000)

Two authors (AM and SS) independently screened study titles and abstracts to ascertain eligibility for full-text assessment, with any discrepancies resolved through consultation with a senior author (HR)