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Cruzado JM, Rico J, Grinyo JM

Semaglutide-based therapies have been approved by the US Food and Drug Administration for the treatment of type 2 diabetes ( Ozempic / Rybelsus ) and chronic weight management ( Wegovy ), highlighting the major clinical impact of GLP-1Rtargeted therapeutics in metabolic disease [3,4]

It signals the pancreas to release insulin, slows gastric emptying so food stays in the stomach longer, and communicates with the brain appetite centers to reduce hunger

The Bottom Line GLP-1 medications drive weight loss

Savvy players track sample sizes, compare developer notes, and avoid drawing conclusions from limited runs

Sofia Bouhlal (Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism) for initial coordination of the samples and data